Motif ID: TAL1_TCF{3,4,12}.p2

Z-value: 0.631


Transcription factors associated with TAL1_TCF{3,4,12}.p2:

Gene SymbolEntrez IDGene Name
TAL1 6886 T-cell acute lymphocytic leukemia 1
TCF12 6938 transcription factor 12
TCF3 6929 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF3chr19_-_16012460.665.1e-03Click!
TCF4chr18_-_51219880-0.505.0e-02Click!
TAL1chr1_-_47468029-0.411.2e-01Click!
TCF12chr15_+_54998264-0.136.3e-01Click!


Activity profile for motif TAL1_TCF{3,4,12}.p2.

activity profile for motif TAL1_TCF{3,4,12}.p2


Sorted Z-values histogram for motif TAL1_TCF{3,4,12}.p2

Sorted Z-values for motif TAL1_TCF{3,4,12}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TAL1_TCF{3,4,12}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_134976965 2.663 TF
transferrin
chr17_+_38256710 1.431 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr16_-_29817841 1.339 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr2_-_158008763 1.142 NM_004288
CYTIP
cytohesin 1 interacting protein
chr12_-_101835183 1.087 PAH
phenylalanine hydroxylase
chr1_-_149004852 1.059 CTSS
cathepsin S
chr1_-_158948176 0.945 NM_001778
CD48
CD48 molecule
chr12_-_101835510 0.934 NM_000277
PAH
phenylalanine hydroxylase
chr12_-_101835026 0.921 PAH
phenylalanine hydroxylase
chr22_+_23309717 0.731 NM_013430
GGT1
gamma-glutamyltransferase 1
chr19_+_40224480 0.708 HPN
hepsin
chrX_-_154216929 0.701 NM_001289
CLIC2
chloride intracellular channel 2
chr14_-_93919305 0.699 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_-_41811916 0.694 NM_001167827
TFEB
transcription factor EB
chr8_-_81155564 0.653 NM_001025252
TPD52
tumor protein D52
chr1_-_149004879 0.631 CTSS
cathepsin S
chr16_+_11966464 0.618 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr10_-_73518772 0.596 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr1_+_32489426 0.558 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr11_+_66979393 0.547 NM_145200
CABP4
calcium binding protein 4
chr1_-_149004916 0.504 NM_004079
CTSS
cathepsin S
chr10_+_7785331 0.485 ITIH2
inter-alpha (globulin) inhibitor H2
chr2_-_96320185 0.457 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr22_+_38652555 0.450 GRAP2
GRB2-related adaptor protein 2
chrX_+_46825179 0.449 RGN
regucalcin (senescence marker protein-30)
chr7_+_94130752 0.424 PEG10
paternally expressed 10
chr10_+_7785347 0.417 ITIH2
inter-alpha (globulin) inhibitor H2
chr15_-_58706934 0.408 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr10_+_80743769 0.368 ZMIZ1
zinc finger, MIZ-type containing 1
chr10_+_7785235 0.345 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr1_+_50342168 0.339 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr17_+_72827227 0.330 SEPT9
septin 9
chr5_-_142764168 0.316 NM_001018076
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr12_-_121753795 0.314 NM_177551
GPR109A
G protein-coupled receptor 109A
chr6_-_33028790 0.313 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr1_+_205328834 0.303 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr19_-_40996040 0.292 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chrX_+_128741562 0.290 NM_018990
SASH3
SAM and SH3 domain containing 3
chr19_-_11549441 0.287 ACP5
acid phosphatase 5, tartrate resistant
chr6_-_11490487 0.282 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr14_-_106249999 0.281 IGHA1
immunoglobulin heavy constant alpha 1
chr7_+_94130673 0.278 PEG10
paternally expressed 10
chr19_+_17499064 0.277 FAM129C
family with sequence similarity 129, member C
chr7_-_36992221 0.267 NM_130442
ELMO1
engulfment and cell motility 1
chr22_-_41672990 0.265 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr12_+_118590039 0.265 NM_006253
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr19_-_11549484 0.263 ACP5
acid phosphatase 5, tartrate resistant
chr9_+_35663852 0.260 NM_001216
CA9
carbonic anhydrase IX
chr10_+_7785290 0.255 ITIH2
inter-alpha (globulin) inhibitor H2
chrX_-_33267646 0.254 NM_000109
DMD
dystrophin
chr1_+_221168388 0.253 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr2_+_68445821 0.238 NM_002664
PLEK
pleckstrin
chr9_-_129707392 0.234 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chrX_-_2896285 0.230 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr10_-_14090459 0.230 FRMD4A
FERM domain containing 4A
chr19_+_18069596 0.229 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr18_+_27425727 0.226 NM_000371
TTR
transthyretin
chr11_-_66431910 0.226 NM_022172
PC
pyruvate carboxylase
chr2_-_183095308 0.221 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr2_-_25320299 0.203 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr22_+_34979118 0.199 APOL1
apolipoprotein L, 1
chr1_+_205329206 0.196 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr1_+_17817397 0.195 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chrX_+_128741578 0.187 SASH3
SAM and SH3 domain containing 3
chr12_-_46405477 0.186 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr14_+_38804226 0.185 NM_203354
CTAGE5
CTAGE family, member 5
chr20_+_45564007 0.183 NM_001174087
NM_001174088
NM_006534
NM_181659
NCOA3



nuclear receptor coactivator 3



chr19_-_11549508 0.179 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr19_-_38052481 0.178 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr14_-_93829309 0.177 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr22_+_20880112 0.172


chr11_-_128399218 0.171 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr1_-_92724181 0.170 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr15_+_56511466 0.167 NM_000236
LIPC
lipase, hepatic
chr1_+_26728846 0.166 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr21_-_33107813 0.166 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr12_-_7153068 0.165 NM_016546
C1RL
complement component 1, r subcomponent-like
chr5_+_139856688 0.164 ANKHD1
ankyrin repeat and KH domain containing 1
chr22_+_34979062 0.163 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr13_+_96672541 0.159 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr3_+_73193499 0.157 NM_018029
EBLN2
endogenous Borna-like N element-2
chr10_-_75127559 0.153 NM_001144000
AGAP5
ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
chr2_-_166638376 0.149 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chrX_-_110400406 0.146 NM_014289
CAPN6
calpain 6
chr16_+_2528022 0.144 PDPK1
3-phosphoinositide dependent protein kinase-1
chrX_-_32340291 0.143 NM_004011
NM_004012
DMD

dystrophin

chr19_-_44060729 0.141 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr8_+_21967008 0.140 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr16_+_2527990 0.139 PDPK1
3-phosphoinositide dependent protein kinase-1
chr6_+_43005126 0.135 CNPY3
canopy 3 homolog (zebrafish)
chr10_+_5228756 0.130 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr1_+_50344550 0.129 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr15_+_72687765 0.122 NM_003992
CLK3
CDC-like kinase 3
chr3_-_11598829 0.122 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr2_-_25320582 0.121 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_+_100099353 0.119 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr1_-_9052207 0.116 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr8_+_9450800 0.114 TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr3_-_180467483 0.112 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr16_+_2528001 0.112 PDPK1
3-phosphoinositide dependent protein kinase-1
chr9_-_91284430 0.109 NM_001142287
NM_006378
SEMA4D

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

chr2_+_136005423 0.109 NM_015361
R3HDM1
R3H domain containing 1
chr10_-_69267774 0.108 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr16_+_88207216 0.107 NM_001128141
DPEP1
dipeptidase 1 (renal)
chr3_+_63859114 0.102 NM_001177387
ATXN7
ataxin 7
chr1_-_9052253 0.101 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr7_+_94377145 0.101 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr11_+_46651090 0.100 ATG13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr6_+_36318922 0.097 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr10_+_71482362 0.097 NM_018649
H2AFY2
H2A histone family, member Y2
chr7_+_72883128 0.095 NM_001305
CLDN4
claudin 4
chr15_+_79276273 0.095 NM_001172128
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chrX_-_74292800 0.093 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr17_-_64823368 0.091 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr2_-_89294466 0.089 IGKC
immunoglobulin kappa constant
chr17_-_46479127 0.087 SPAG9
sperm associated antigen 9
chr16_+_10430225 0.087 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr19_-_4289750 0.085 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr17_+_6599879 0.083 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr3_+_52788976 0.081 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr6_+_167456230 0.080 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr15_-_72281833 0.077 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr4_-_185921384 0.077 ACSL1
acyl-CoA synthetase long-chain family member 1
chr5_+_67558217 0.072 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_+_72827185 0.071 NM_006640
SEPT9
septin 9
chr17_-_72234224 0.071 JMJD6
jumonji domain containing 6
chr3_+_142525744 0.069 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr3_+_120982020 0.067 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr17_-_53761119 0.067 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr6_-_43122473 0.065 CUL7
cullin 7
chr1_+_149221122 0.064 NM_003568
ANXA9
annexin A9
chr3_-_121550767 0.063 NM_001099678
LRRC58
leucine rich repeat containing 58
chr22_-_34886727 0.063 NM_145640
APOL3
apolipoprotein L, 3
chr15_+_22652790 0.062 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr3_+_10043123 0.061 FANCD2
Fanconi anemia, complementation group D2
chr17_-_16816113 0.061 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr5_-_131907071 0.061 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr1_+_36545283 0.061 NM_024676
SH3D21
SH3 domain containing 21
chr17_-_72234261 0.061 JMJD6
jumonji domain containing 6
chr15_-_88143721 0.060 ANPEP
alanyl (membrane) aminopeptidase
chr17_-_77396372 0.059 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr5_-_169657395 0.058 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_-_7739591 0.057 NM_020634
GDF3
growth differentiation factor 3
chr14_+_71065794 0.056 NM_015556
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr5_+_161208119 0.055 NM_001127645
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr18_+_41659542 0.053 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr1_-_151280201 0.053 NM_006945
SPRR2D
small proline-rich protein 2D
chr13_-_26232777 0.053 NM_005288
GPR12
G protein-coupled receptor 12
chr19_-_14853166 0.053 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr19_+_50887580 0.052 NM_001163377
NM_017659
QPCTL

glutaminyl-peptide cyclotransferase-like

chr6_-_22405708 0.052 NM_000948
PRL
prolactin
chr8_-_20084892 0.052 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr12_+_63084317 0.051 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr12_-_129568362 0.050 NM_015347
RIMBP2
RIMS binding protein 2
chrX_+_46967360 0.048 NM_001170460
CDK16
cyclin-dependent kinase 16
chr6_-_30236667 0.048 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr1_-_38185312 0.047 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr1_+_24713396 0.046 RCAN3
RCAN family member 3
chr3_+_10043097 0.045 NM_001018115
NM_033084
FANCD2

Fanconi anemia, complementation group D2

chr3_-_188936941 0.044 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr6_+_31622606 0.044 NM_001144962
NM_001144963
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr4_+_114433551 0.042 ANK2
ankyrin 2, neuronal
chr6_-_32268267 0.041 GPSM3
G-protein signaling modulator 3
chr2_+_73911477 0.040 STAMBP
STAM binding protein
chr19_+_10673105 0.040 NM_031209
QTRT1
queuine tRNA-ribosyltransferase 1
chr1_-_218286456 0.040 EPRS
glutamyl-prolyl-tRNA synthetase
chr6_+_126282078 0.039 NCOA7
nuclear receptor coactivator 7
chr4_-_83566246 0.039 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr11_+_298106 0.039 NM_006435
IFITM2
interferon induced transmembrane protein 2 (1-8D)
chr4_-_83566045 0.036


chr3_+_173240983 0.036 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr11_+_113165134 0.035 LOC390251
SH3-domain GRB2-like 1 pseudogene
chr1_-_218286476 0.034 EPRS
glutamyl-prolyl-tRNA synthetase
chr16_-_70168449 0.034 NM_000353
TAT
tyrosine aminotransferase
chr7_+_31693155 0.032 NM_001145123
NM_006658
C7orf16

chromosome 7 open reading frame 16

chr5_+_161208475 0.031 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_-_27871306 0.031 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr1_+_242283129 0.030 NM_006352
ZNF238
zinc finger protein 238
chr7_+_75977680 0.029 NM_030570
NM_182684
UPK3B

uroplakin 3B

chr5_-_88235624 0.027 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr5_-_178977441 0.026 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr4_+_154397975 0.026 TRIM2
tripartite motif containing 2
chr16_+_66836798 0.025 PLA2G15
phospholipase A2, group XV
chr12_-_14024187 0.025 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr12_+_61240542 0.024 MON2
MON2 homolog (S. cerevisiae)
chr8_+_9450849 0.024 NM_003747
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr16_+_66836707 0.023 NM_012320
PLA2G15
phospholipase A2, group XV
chr4_-_116254381 0.023 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr13_-_40491405 0.022 ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_+_40533622 0.022 NM_007187
WBP4
WW domain binding protein 4 (formin binding protein 21)
chr2_-_86704470 0.022 NM_001198951
NM_001198952
NM_005667
RNF103


ring finger protein 103


chr2_+_232979795 0.022 NM_031313
ALPPL2
alkaline phosphatase, placental-like 2
chr16_-_29781842 0.022 NM_006319
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr5_+_154072654 0.021 NM_015315
LARP1
La ribonucleoprotein domain family, member 1
chr7_+_141124710 0.021 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr19_-_59438411 0.020 NM_024318
LILRB3
LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr3_+_49019498 0.019 NM_018031
WDR6
WD repeat domain 6
chr3_-_25658829 0.018 TOP2B
topoisomerase (DNA) II beta 180kDa
chr21_-_44506526 0.018 NM_013369
NM_175867
DNMT3L

DNA (cytosine-5-)-methyltransferase 3-like

chr2_+_191009265 0.017 MFSD6
major facilitator superfamily domain containing 6

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.